In 1981 first musique-concrete-experiments with magnetophones and shortwave-radio signals have been recorded on various cassettes, followed by intense activities in the European tape-scene between 1985 and 1993.

Together with Miguel A. Ruiz from Madrid, Siegmar Fricke founded the industrial project Efficient Refineries. Further collaborations with the Italian sound-artists Maurizio Bianchi and Giancarlo Toniutti were released.

Since 2001 Siegmar Fricke characterizes his musical universe as «Pharmakustik»: audioclinical investigation, sound-research, implantation and re-implantation of acoustic fragments; exclusion of harmonies/melodies/traditional song-structures, generation of completely electronic and highly abstract tissues, intermodulating soundpools related to medical subjects, neurochemical ambiences, formantmodulation of selected voice-particles, bitcrushed fractures of rhythm, complex combinations of plugins/modulators/effect-periphery.